(The FDA weighed in on its view of RWE in the New England Journal, December 8, 2016, here.)
The Green Park Collaborative, organized by the Baltimore-based Center for Medical Technology Policy (CMTP), has set up a resource webpage with multiple detailed documents to help parties assess and validate the quality of Real World Evidence.
Website here. 39-page white paper on the RWE Decoder project, here.
For a February 21, 2017 editorial in JAMA on observational evidence, see here. For a July 2016 FDA guidance on RWE, here.