Can CHAT GPT 5 psychoanalyze MolDx? We feed it some documents to find out.
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One of the flagship uses of AI is to summarize things - to summarize 3 PDFs as mini-review of the 3 peer-reviewed papers, to summarize a long New York Times article, and so on.
But here's a more offbeat use: Can Chat GPT make sensible inferences about what the human author(s) of a document was really thinking?
This month, MolDX held a contractor advisory meeting (CAC) on the topic of molecular tests to classify Barrett's esophagus. While the transcript hasn't been released yet, MolDX did post a list of about 15 questions for the expert panelists. I uploaded that one item to Chat GPT and asked for feedback, if any, on what the MolDx author(s) were thinking. It found the questions were written in a balanced way, yet some denote a tone of skepticism - and so on.
All well and good. Then I noticed that MolDx had also held a CAC on this topic in 2021, and had also written a noncoverag LCD in this area in 2023.
That gave me a new idea. This time, I took all three documents - questions 2021, LCD 2024, questions 2025 - and gave them to Chat GPT and asked for an assessment of the "evolution" of MolDX thinking, and if this longitudinal view gives more insights into the current 2025 questions. Chat GPT gave a detailed assessment and found that it did.
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Not Right or Wrong
This is an area without a clear "right or wrong." It's more like, if you ask 10 college students to review The Great Gatsby, you'll get ten different essays. Some will like it, some will hate it, some will focus on characters, others on plot, etc. Similarly, there 's not right or wrong way to look at the three MolDx PDFs and discuss what the authors might be thinking. It's a worthwhile exercise only to the extent that a human reader sees the AI analysis, and catches some insights that hadn't occurred to him/her but that make sense when you see them.
See the AI Assessment in SIDEBAR
I've put the AI discussion in a sidebar. The first AI answer handled the 2025 questions alone. The second AI answer (clearly marked) was based on the three documents written over 5 years.
https://bqwebpage.blogspot.com/2025/09/moldx-2025-questions-for-barrett-cac.html
Get the 2021, 2023, 2025 PDFs in one zip file here:
https://drive.google.com/file/d/1ptfthX3Uv1yQBLW-jcENnmsJDwwAw9w7/view?usp=sharing
