AMA releases new PLA codes quarterly, and its code list for December 30, 2024 is posted.
https://www.ama-assn.org/system/files/cpt-pla-codes-long.pdf
AMA updates this PDF on a rolling basis - when the new annual book is issued, it drops the last four quarters of PLA updates (since they are now annually published).
For January 1, 2025, there are 21 new codes, five updated codes, and I tally five deleted codes.
The FDA-approved Illumina TRUSIGHT code (a 517-gene tumor panel) is effective April 1, 2025, code 0543U.
The Guardant Shield test, blood-based screening for colorectal cancer, is effective April 1, 2025, code 0537U.
Like Rady Children's in San Diego, UCSF gets a rapid whole-genome code, 0532U, April 1, 2025.
Quest's plasma Alzheimer test is deleted (0346U), but there are several other new Alzheimer PLA codes from other sources, including Quanterix (0551U, P217 tau). Fujirebio gets codes for plasma GFAP and plasma neurofilament (0548U, 0547U).
