Thursday, August 17, 2023

AI Corner: Contrast and Compare Two Genomeweb Articles (Children's Hospital Colorado and Duke)

This week, Genomeweb had two somewhat similar headlines:

  • Children's Hospital Colorado Embraces Precision Medicine via 'Institutional Approach'
  • Duke University Health System Aims to Enroll 100K Participants in Precision Medicine Study

We know that ChatGPT can summarize articles intelligently and efficiently, but here, I was more interested in "contrast and compare" to see what it would come up with on its own, without further pointers from me.

Below, the task to ChatGPT was summarize #1, summarize #2, and then contrast and compare.


Summary of "ARTICLE ONE" - Children's Hospital Colorado Embraces Precision Medicine via 'Institutional Approach':

  • Children's Hospital Colorado has established the Precision Medicine Institute, a philanthropy-funded effort aimed at integrating precision medicine into their organization. The institute operates as a "horizontal" service line, working alongside clinical and operational departments. It focuses on developing diagnostics, therapies, and patient education related to precision medicine. The goal is to ensure that precision medicine interventions reach patients by addressing access barriers and delivery mechanisms. The institute collaborates with other hospital departments, such as Precision Diagnostics Laboratory, to enhance patient care through precision medicine. 
  • The institution-wide approach aims to make precision medicine a core aspect of medical practice. The success of the institute is measured by patient access to genetic testing, timely test result delivery, usefulness of results in treatment, clinical trial enrollments, and improved patient outcomes. 
  • The institute is primarily funded through philanthropy and aims to become self-sustaining.

Summary of "ARTICLE TWO" - Duke University Health System Aims to Enroll 100K Participants in Precision Medicine Study:

  • Duke University Health System and Nference, a software company, are launching the OneDukeGen Genomic Sequencing Study and Biorepository. The collaboration aims to recruit over 100,000 Duke Health patients to donate blood or saliva samples and health data for DNA and RNA sequencing. Researchers intend to analyze the data to uncover patterns that could lead to new detection, treatment, prevention, or cure methods for various diseases. Leftover samples will be stored in a biorepository for future research. 
  • The study employs the MyChart patient portal to engage potential participants and plans to involve diverse community groups. 
  • The collaborative effort aims to bridge the gap between scientific discovery and clinical practice, revolutionizing healthcare delivery at Duke.

Contrast and Comparison:

Both articles focus on the integration of precision medicine into healthcare institutions, albeit with distinct approaches and emphases:
  1. Institutional Approach vs. Research Study: The Children's Hospital Colorado article discusses the establishment of an institutional framework, the Precision Medicine Institute, to weave precision medicine into patient care across various hospital departments. In contrast, the Duke University article highlights the launch of a research study, the OneDukeGen Genomic Sequencing Study and Biorepository, with a specific focus on collecting genomic data from patients to advance scientific understanding.
  2. Scope and Focus: The Children's Hospital Colorado's approach involves integrating precision medicine broadly across the organization, focusing on diagnostics, therapies, education, and patient access. Duke University's effort centers on a research study with the primary goal of analyzing genomic data to uncover patterns for disease understanding and potential treatments.
  3. Funding: The Children's Hospital Colorado's Precision Medicine Institute is primarily funded through philanthropy and seeks self-sustainability. On the other hand, Duke University collaborates with a software company, Nference, to leverage their analytics platform for the research study.
  4. Patient Engagement: Children's Hospital Colorado emphasizes collaboration with other departments within the organization to promote precision medicine adoption. Duke University engages potential participants through the MyChart patient portal and plans to involve community groups for a diverse cohort.
  5. Outcome Measurement: The success of the Precision Medicine Institute is evaluated based on patient access to genetic testing, timely result delivery, usefulness of results, clinical trial enrollments, and patient outcomes. In the case of the Duke study, success is measured by uncovering patterns and connections between genomic data and patient health data to enhance disease understanding and potential treatments.
In summary, both institutions are actively embracing precision medicine, but the Children's Hospital Colorado takes an institutional approach to integrate it across patient care, while Duke University focuses on a research study to uncover insights from genomic data.

Nference has raised over $150M. [BQ].
GPT studies NFERENCE here. [BQ].

Are you aware of any projects similar to the DUKE project?

As of my last knowledge update in September 2021, there were several projects similar to the Duke University precision medicine project, aimed at collecting genomic data from large cohorts of participants for research purposes. However, please note that developments in this field may have occurred since then. Here are a few examples:

All of Us Research Program (formerly Precision Medicine Initiative): This is a project by the National Institutes of Health (NIH) in the United States. It aims to gather health data from a diverse group of one million or more people across the country to advance precision medicine. Participants provide genetic data, lifestyle information, and health records to fuel research on a wide range of health conditions.

UK Biobank: This large-scale project in the United Kingdom collects data and biological samples from 500,000 participants to better understand the links between genetics, lifestyle, and disease. It provides a valuable resource for researchers studying various health conditions.

Personal Genome Project: Founded by geneticist George Church, this project aims to create a public genomic database by recruiting volunteers willing to share their genetic and health information. It emphasizes open access to data for research purposes.

Framingham Heart Study: Although not solely focused on genomics, this long-running study has collected extensive cardiovascular data from multiple generations over several decades. It has contributed to our understanding of heart disease risk factors.

American Gut Project: This initiative collects microbiome data (bacterial communities in and on the human body) from participants to understand the role of the microbiome in health and disease.

Genotype-Tissue Expression (GTEx) Project: This project aims to create a comprehensive public resource that describes genetic effects on gene expression across multiple human tissues. It provides valuable insights into how genetic variations influence gene activity.

100,000 Genomes Project (UK): This project focused on sequencing the genomes of patients with rare diseases and cancers, aiming to improve diagnosis and treatment options.

China Kadoorie Biobank: This study, based in China, aims to collect data and biological samples from half a million participants to study genetic, environmental, and lifestyle factors influencing chronic diseases.

Remember that the landscape of precision medicine and genomics research is rapidly evolving, and new projects and initiatives may have emerged since my last update. It's always a good idea to consult recent sources or news to get the most up-to-date information on similar projects.


Bonus 2.  I asked GPT4 some questions about my office video camera, a Sony ZV1, and it sounds like it is really "thinking" spatially and logically, in providing answers.  Here.

Bonus 3I asked GPT4 to summarize the Georgia election indictment, also discuss it from the viewpoint of Lewis Black, and from the viewpoint of an originalist constitutional scholar.  Here.