On May 14, 2025, AHRQ released a 140-page review of the field of Multi Cancer Early Detection tests. The systematic review focused on 20 studies to date, 7 of which it found were higher quality. They report only one study had enough assessment of harms; therefore, it was too early to do a risk-benefit calculation of harms.
Find the report here:
https://effectivehealthcare.ahrq.gov/products/cell-free-dna/research